Arterial hypertension is one of the most serious problems of modern health care. This disease is multifactorial and, as a rule, develops in people genetically predisposed to it, which is largely due to the presence of genetic polymorphisms of genes involved in the regulation of blood pressure. This article presents the results of the study of the occurrence frequencies of single nucleotide polymorphisms of the ADD1α 1378 G>T; AGT 521 C>T; AGTR1 1166 A>C; CYP11B2 -344 T>C; GNB3 825 C>T; NOS3 -786 T>C и 894 G>T genes in different ethnic groups of residents of the Arctic zone of the Republic of Sakha (Yakutia), suffering from essential arterial hypertension. To reveal the polymorphisms mentioned above, the real-time PCR method was used with detection of the melting point of duplexes. The surveyed volunteers (n = 139) were grouped into the following groups: NIEGHN (non-indigenous ethnic groups of the High North), IPHN (indigenous peoples of the Far North) and Sakha (representatives of the Sakha people).The purpose of this study was to determine the presence of statistically significant differences between the studied ethnic groups. As a result, statistically significant (p ≤ 0.05) differences between different ethnic groups were identified, at points CYP11B2 -344 T> C; NOS3 -786 T> C and 894 G> T; ADD1α 1378 G>T; AGT 521 C>T and AGTR1 1166 A>C. It can be assumed that the differences identified are due to the ethnic characteristics of the groups in question.

Defining a stage of liver fibrosis is critical in choosing treatment tactics. The predictive models based on calculation of indirect fibrosis indexes remain relevant. A research objective was to compare indirect noninvasive methods of liver fibrosis diagnosis in patients with chronic viral hepatitis in Yakutia. The research covered 140 patients with chronic viral hepatitis: 77 women (55%) and 63 men (45%) aged 21-55 years (average age of 45.78±14.92 years). The severity of fibrosis was estimated by the APRI scale. We analyzed the data from biochemical tests, general blood test and coagulogramm. APRI detected stage F1 in 7 (5%), stage F2 in 23 (16.4%), stage F3 and F4 in 34 (24.3%) and 76 (54.3%), respectively, CVH patients. Three groups of patients were created: with initial fibrosis (F1/2, n = 30), widespread fibrosis (F3, n = 34), and the fibrosis that transformed into cirrhosis (F4, n = 76). In the groups of patients with F1/F2, F3 and F4, median FIB-4 values were 2.56 (LQ-UQ 2.22-2.73), 2.73 (2.54-2.94) and 3.57 (3.27-4.11), respectively. The FIB-4 value directly correlated with the APRI index (rS = 0.68; p <0.000001). In F1/F2, F3 and F4 groups, the median Fibrosis Index values were 3.56 (LQ-UQ 3.01-3.88), 3.73 (2.14-4.54) and 4.57 (3.47-4.21), respectively. Fibrosis Index did not coincide with results of APRI, which signals a high (12.7%) frequency of false results. The results of FIB-4 in 136 out of 140 sick HVH patients coincided with the results of the APRI index, which indicates high diagnostic precision. Thus, the offered approach provides high (97%) diagnostic accuracy to estimate severity of fibrosis at patients with chronic viral hepatitis.

Coronary heart disease (CHD) continues to maintain one of the leading positions in the structure of mortality in the population of developed countries. The most common cause of myocardial ischemia is atherosclerotic lesion of the coronary arteries that leads to narrowing of these arteries, which causes a decrease in myocardial perfusion at rest or limits the possibility of its adequate increase with an increase in myocardial oxygen demand. The lesion of the left coronary artery trunk is one of the main factors determining the increase in morbidity and mortality of patients with CHD, detected in about 11% of patients with CHD. A lesion of over 50% is considered hemodynamically significant and allows patients to be classified as high risk of sudden death. The prognosis for such patients receiving conservative therapy without surgical treatment is unfavorable and associated with high mortality. According to the latest European guidelines, choosing the revascularization technique requires a Heart Team discussion to define the best revascularization strategy in relation of efficiency and safety of the treatment strategy for acute coronary syndrome.

Adolescence and youth is one of the most significant risk factors for the formation of various dependencies. Recently, due to the computerization of society, cyber-addiction has become widespread, to which schoolchildren are more susceptible due to their fragile psyche. The Internet is becoming the center of their attention; there is a loss of interest in life; with noaccess to the virtual reality, there appears a feeling of emptiness and irritability. These conditions result in socio-psychological maladaptation and anxiety-depressive disorders, which, in turn, are favorable soil for the development of suicidal behavior. The relevance of this topic is due to the annual increase in the number of digital technology users worldwide, which inevitably leads to an increase in the number of Internet addicts. The aim of the work is to identify the effect of computer addiction on the occurrence of anxiety-depressive disorders, and the main tasks are to reveal the prevalence of cyber addiction, as well as to determine the level of anxiety and depression in schoolchildren. The study used the hospital anxiety and depression scale test method (HADS) and a questionnaire method using a specially designed questionnaire. The analysis of the obtained data showed that 29 % of schoolchildren are addicted to the Internet and computer technology. All students with signs of cyber addiction have a high level of anxiety depression.

Old age is the most important and independent risk factor for atrial fibrillation (AF). According to the report of the World Health Organization, life expectancy is growing rapidly all over the world. Thus, in the Russian Federation, as of 2015, the proportion of people over 60 years old was 20-24 %, while by 2050 an increase to 25-29 % is predicted. In the elderly and senile age, there is a high risk of atrial fibrillation (AF). The proportion of patients with AF at the age of 65-85 years reaches 70 %, and the average age of patients with AF is 75 years. When deciding on the appointment of antithrombotic therapy for an elderly patient with AF, it is necessary to assess the risk of developing stroke without treatment and the risk of developing bleeding, especially intracranial, during treatment. In addition, elderly patients suffer from many comorbidities. The article uses the HAS-BLED and CHA2DS2-VAS scales used to assess the risk of thromboembolic and hemorrhagic complications and approaches to antithrombotic therapy in elderly and old people during inpatient treatment of the Geriatric Center of the Republican Hospital № 3. Low anticoagulant therapy was noted at the outpatient stage - 42.6 %, 47.8 % of patients were on disaggregant therapy (aspirin). During hospitalization, new oral anticoagulants of direct action were prescribed and recommended at discharge in 56.6 % of cases, warfarin in 23.6 % of cases. Aspirin is replaced with new oral anticoagulants of direct action in 38 % of cases.

For large populations, Tthe need for large populations in dental care is identified using the DMFCSR- index, which allows you to comparinge and characterizinge the level of dental care, intensity and increase in of dental caries among the population by the studied criteria (in this case, both the DMF index CSR-index and its components). region, and qualitative and quantitative indicators of the work of dentists efficiency. At the same time, the DMF index KPU index is convenient and easy to use in practice, informative and objective. Therefore, the relevance of the survey and the use of this index in diagnostic examinations of residents of boarding schools of a neuropsychiatric hospitalsprofile is obviousnot in doubt. Materials and methods. Using Tthe methods of questioning, analysis of data from case histories, clinical objective examination, we studied the features of the dental status in 691 residents of neuropsychiatric hospitals, suffering from mental retardation, psychoneurological hospitals in the eastern zone of the Krasnoyarsk KraiTerritory, suffering from mental retardation. Results. The use of the modern DMF index CSR-index made it possible to identify almost 100 % need in for orthopedic dental care in all the examined, as well as people with the a carious process and poor dental filling. The Eexamination with using the DMF index CSR-index allows you to planning, systematizinge and identification determine of the indications for the full range of dental services for the examined individuals.

Young patients can develop stroke under a variety of conditions, some of which are quite rare. Thrombophilia is one of the probable and important causes of stroke in young patients. The incidence of stroke at a young age is an important socio-economic problem for both the state and society as a whole. The combination of the patient’s diagnosis of thrombophilia and various risk factors, such as dyslipidemia, diabetes mellitus, arterial hypertension, smoking, etc. leads to an increased likelihood of developing a stroke. Thrombophilia can be hereditary and acquired. For hereditary thrombophilia, the carriage of certain polymorphisms of genes responsible for the coagulation properties of blood is characteristic. In clinical practice, molecular genetic studies are conducted on polymorphisms of coagulation factor genes. Of greatest interest is the determination of the carriage of polymorphisms of the PAI-1 gene, responsible for the inhibition of type 1 plasminogen activator. Identification of the mutant homozygous of this gene may be associated with the risk of developing ischemic stroke at a young age. The harbingers of a stroke in this group of patients are often transient cerebrovascular accidents (transient ischemic attacks) that occur before a stroke. Unfortunately, often such symptoms are ignored by patients or remain unrecognized and only subsequently identified retrospectively.

Pharmacovigilance is an activity relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. The risk of side effects exists with any medication. The article describes of the organization of a pharmacovigilance system in France as a part of a common European system where using standard methods and technologies for recording drug-associated adverse events. The authors describe different levels of organization of pharmacovigilance, the movement of information in the system. The regional pharmacovigilance centers are the main unit whose tasks include collecting information from patients and healthcare professionals, evaluating and documenting this information, and transferring it to the National Health Agency. In addition, the Centers also train students, pharmaceutical workers, healthcare practitioners, members of the public and patients. It is shown that a feature of the French system for monitoring side effects of drugs is the assessment of causality, relation between taking the drug and the manifestation of side effects. To record these events, artificial intelligence technologies are widely used, in the form of Internet portals for medical workers and patients.

The increase in morbidity and the presence of factors that negatively affect the health status of students in modern conditions are the main reason for improving preventive measures. The article presents an analysis of the data of a survey of students of secondary medical educational institutions in the SR (Ya). Indeed, one of the main tasks of the state in the field of education is the comprehensive care of health, physical education and the development of students, with the aim of releasing qualified medical personnel of the middle level. The study showed that future doctors care little about their health. At the same time, future doctors (rather because of the perceived need and specificity of the profession) are more active in promoting healthy lifestyles among others. The respondents consider the lack of time and money to be the main reasons that prevent them from taking care of their own health. At the same time, they do not have a properly formed concept of a healthy lifestyle, since future medical workers, first of all, must take care of their own health, and monitor the way and quality of life.