NON-INVASIVE DIAGNOSIS OF LIVER FIBROSIS
https://doi.org/10.25587/SVFU.2020.21.4.005
Abstract
The article provides an overview of non-invasive tests for diagnosing the activity and stage of fibrotic changes in liver tissue. Despite the high information content of biopsy, this invasive procedure has its drawbacks. The most common complication is bleeding, which occurs in 0.1-4.6 % of biopsies performed. Therefore, the availability and greater acceptance of non-invasive tests is now increasing. There are direct and indirect markers of liver fibrosis, the latter being used for NIT based serum markets. Of these, the most studied are the FibroTest group of tests, APRI index, FIB-4, AST / ALT ratio (AAR). In addition to the named NITs, there are other non-proprietary tests: the Lok index, which uses the level of platelets, AST, ALT, and INR; Fornes index - cholesterol, GGT, platelet count and age; King’s scale - age, AST, INR, platelet count; AAR is the ratio of AST and ALT, as well as other predictive models. The article also discusses ultrasound techniques: shear wave elastography, transient elastography (TE), point shear wave elastography (pSWE), multivariate shear wave elastography (2D-SWE). Considering the low specificity of NITs based on serum markers, the invasiveness of biopsy, there is a tendency to search for innovative diagnostic methods with high sensitivity. These methods include MRI elastography and T1 mapping of the liver.
About the Author
Y. A. Soloveva
Institute of Medicine, M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
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For citations:
Soloveva Y.A. NON-INVASIVE DIAGNOSIS OF LIVER FIBROSIS. Vestnik of North-Eastern Federal University. Medical Sciences. 2020;(4):45-54. (In Russ.) https://doi.org/10.25587/SVFU.2020.21.4.005
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