Cerebral venous thrombosis in young women in the Sakha Republic (Yakutia)

The aim of the study was to investigate the clinical and neuroimaging characteristics of cerebral venous thrombosis (CVT) in young women in the Sakha Republic (Yakutia) for the period 2014–2025. A retrospective and prospective cohort study was conducted using a continuous method. 41 female patients aged 18–44 years with a verified diagnosis of CVT according to the data of the vascular centers of the Sakha Republic (Yakutia) from 2014 to 2025 were included. An analysis of complaints and anamnesis, assessment of neurological status according to the Glasgow Coma Scale and NIHSS, analysis of magnetic resonance imaging data with time-offlight venography were performed. The main risk factors were the use of combined oral contraceptives (41.5 %), pregnancy and the postpartum period (24.4 %), and iron deficiency anemia (24.4 %). The clinical picture was dominated by cephalgic syndrome (70.6). Epileptic seizures at onset or during the acute period were recorded in 51.2 % of patients, which significantly exceeds the data of large international registries (25-34 %). According to neuroimaging data, combined lesions of the sinuses and veins of the brain were detected in 53.2 % of patients, with the transverse sinus most frequently involved (70.7 %). Parenchymal changes of various nature (cerebral infarction, hemorrhagic transformation, intracerebral hematoma) were detected in 75.6 % of patients. Cerebral venous thrombosis in young women in Yakutia is characterized by a high frequency of epileptic seizures in the acute period (51.2 %) and a significant proportion of hemorrhagic parenchymal changes (over 40 %). The presence of headaches and epileptic seizures in young women, combined with hemorrhagic lesions based on neuroimaging data, requires the primary consideration of cerebral venous thrombosis. These findings support the need to develop regional clinical guidelines tailored to the ethnic characteristics of the Yakut population.

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