POLYMORPHISMS OF GENES INVOLVED IN THE REGULATION OF ARTERIAL PRESSURE IN VARIOUS ETHNIC GROUPS OF RESIDENTS OF THE HIGH FAR NNORTH OF YYAKUTIA SUFFERING FROMWITH ARTERIAL HYPERTENSION

Arterial hypertension is one of the most serious problems of modern health care. This disease is multifactorial and, as a rule, develops in people genetically predisposed to it, which is largely due to the presence of genetic polymorphisms of genes involved in the regulation of blood pressure. This article presents the results of the study of the occurrence frequencies of single nucleotide polymorphisms of the ADD1α 1378 G>T; AGT 521 C>T; AGTR1 1166 A>C; CYP11B2 -344 T>C; GNB3 825 C>T; NOS3 -786 T>C и 894 G>T genes in different ethnic groups of residents of the Arctic zone of the Republic of Sakha (Yakutia), suffering from essential arterial hypertension. To reveal the polymorphisms mentioned above, the real-time PCR method was used with detection of the melting point of duplexes. The surveyed volunteers (n = 139) were grouped into the following groups: NIEGHN (non-indigenous ethnic groups of the High North), IPHN (indigenous peoples of the Far North) and Sakha (representatives of the Sakha people).The purpose of this study was to determine the presence of statistically significant differences between the studied ethnic groups. As a result, statistically significant (p ≤ 0.05) differences between different ethnic groups were identified, at points CYP11B2 -344 T> C; NOS3 -786 T> C and 894 G> T; ADD1α 1378 G>T; AGT 521 C>T and AGTR1 1166 A>C. It can be assumed that the differences identified are due to the ethnic characteristics of the groups in question.

ADD1α, AGT, AGTR1, CYP11B2, GNB3, NOS3, arterial hypertension, single nucleotide polymorphisms, ADD1α, AGT, AGTR1, CYP11B2, GNB3, NOS3, real-time PCR

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