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POSSIBILITIES OF CORRECTING VASCULAR STIFFNESS UNDER THE INFLUENCE OF STATIN AND SPIRONOLACTONE IN ARTERIAL HYPERTENSION: INTERMEDIATE RESULTS OF THE PROSPECTIVE STUDY OF “ARTERIA-AH”

https://doi.org/10.25587/SVFU.2021.22.1.001

Abstract

The possibility of slowing down vascular remodeling in hypertensive patients with the combined effect of antihypertensive drugs and statins has been studied in few works. The effect of spironolactone on vascular stiffness in relation to the severity of the hypotensive effect in combination therapy has also been insufficiently studied. The aim of the research was to study the dynamics vascular stiffness parameters in hypertension patients of high/very high cardiovascular risk in addition rosuvastatin or spironolactone to combined two-component amlodipine and lisinopril therapy. 90 patients with hypertension were randomized into groups: the first group received a fixed combination of amlodipine/lisinopril, the secons one followed the same regimen of therapy with addition of 20 mg rosuvastatin, the third - in addition to the combination of amlodipine / lisinopril received spironolactone. After 6 months of the therapy, office and average daily blood pressure decreased in all groups, to a greater extent in the group adding spironolactone to therapy. In the rosuvastatin group, a greater degree of decrease in office diastolic blood pressure was noted. The augmentation index significantly decreased in all groups, mainly in the statin supplementation group. In patients who received a fixed combination of amlodipine/lisinopril, only the speed of propagation of the pulse wave in the carotid-femoral decreased, and with the addition of spironolactone and rosuvastatin - and in the carotid-radial.

About the Authors

O. V. Fedorishina
Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation
Russian Federation


A. M. Torunova
Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation
Russian Federation


K. V. Protasov
Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation
Russian Federation


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Review

For citations:


Fedorishina O.V., Torunova A.M., Protasov K.V. POSSIBILITIES OF CORRECTING VASCULAR STIFFNESS UNDER THE INFLUENCE OF STATIN AND SPIRONOLACTONE IN ARTERIAL HYPERTENSION: INTERMEDIATE RESULTS OF THE PROSPECTIVE STUDY OF “ARTERIA-AH”. Vestnik of North-Eastern Federal University. Medical Sciences. 2021;(1):5-10. (In Russ.) https://doi.org/10.25587/SVFU.2021.22.1.001

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