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Myocarditis in Newborns and Cerebral Ischemia: A Systematic Analysis of Cardiocerebral Interactions in the Neonatal Period

https://doi.org/10.25587/2587-5590-2026-3-62-72

Abstract

Characterized by high mortality and the risk of life-threatening complications, newborn myocarditis remains one of the most severe pathologies in the structure of neonatal cardiology. Cerebral consequences, particularly ischemic brain injuries, are often underestimated, although they may determine the long-term neurological prognosis. Aim. To present a systemic analysis of the pathogenesis of cerebral ischemia in newborns with myocarditis from the perspective of P.K. Anokhin’s theory of functional systems, to identify clinical and instrumental predictors, and to substantiate the need for a multidisciplinary approach. Material and methods. A literature review was conducted, and a clinical case from the author’s practice is presented. Results. Cardiocerebral disturbances are based on a mismatch in the functional system that ensures adequate brain perfusion; ischemia can develop even without critical hypotension. Key predictors include reduced heart rate variability, increased resistance index in cerebral arteries, decreased regional oxygen saturation, and latent metabolic disturbances. Conclusion. Newborn myocarditis requires mandatory monitoring of cerebral status using neurosonography, cerebral oximetry, and heart rate variability analysis. An integrative approach is essential for improving outcomes. 

About the Author

I. I. Polikarpova
Yaroslavl State Medical University
Russian Federation

POLYKARPOVA, Irina Ivanovna, Cand. Sci. (Medicine), Docent, Associate Professor, Department of Pediatrics 1, Institute of Pediatrics and Reproductive Health

Yaroslavl



References

1. Chuang Y.Y., Huang Y.C. Enteroviral infection in neonates. Journal of Microbiology, Immunology and Infection. 2019;52(6):851–857. DOI: 10.1016/j.jmii.2019.08.018.

2. Batyan G.M., Tkachenko A.K. Heart diseases in young children: a teaching manual. Minsk: BSMU; 2022:48 (in Russian).

3. Donnellan E.L., Govindan R.B., Ngwa J., Andescavage N., Limperopoulos C., du Plessis A.J. Heart rate variability is associated with self-regulation and stress neurobehavior in preterm infants. Early Human Development. 2025;211:106406. DOI: 10.1016/j.earlhumdev.2025.106406.

4. Steger C., Boegeholz A., Latal B., Feldmann M., Kottke R., Hagmann C., Restin T., Tuura O’Gorman R., Jakab A., Reiner M., Knirsch W. Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery—is there an association? Frontiers in Cardiovascular Medicine. 2025;12:1556289. DOI: 10.3389/fcvm.2025.1556289.

5. Morriss F.H. Jr., Lindower J.B., Bartlett H.L., et al. Neonatal Enterovirus Infection: Case Series of Clinical Sepsis and Positive Cerebrospinal Fluid Polymerase Chain Reaction Test with Myocarditis and Cerebral White Matter Injury Complications. AJP Reports. 2016;6(3):e344–e351.

6. Anokhin P.K. Essays on the physiology of functional systems. Moscow: Meditsina; 1975:447 (in Russian).

7. Sudakov K.V. Systemogenesis. Moscow: Meditsina; 1980:278 (in Russian).

8. Anokhin P.K. Systemogenesis as a general regularity of the evolutionary process. Bulletin of experimental biology and medicine. 1948;26(8):81–99 (in Russian).

9. Volpe J.J. Neurology of the Newborn. 6th ed. Philadelphia: Elsevier; 2018. 1250 p.

10. Smolkova M., Sunwoo J., Kim S.H., Hannon K., Chami H., Cherkerzian S., El-Dib M. Reduced heart rate variability predicts severe intraventricular haemorrhage in extremely preterm infants. Pediatric Research. 2025. DOI: 10.1038/s41390-025-04632-7.

11. Lynch J.M., Winters M.E., Xiao R., et al. Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease. Journal of Thoracic and Cardiovascular Surgery. 2018;156(4):1657–1664.

12. How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children. Journal of Visualized Experiments (JoVE). 2020;(61533). DOI: 10.3791/61533.

13. Abzug M.J. Prognosis for neonates with enterovirus hepatitis and coagulopathy. Pediatric Infectious Disease Journal. 2001;20(8):758–763.

14. Mintzer J.P., Moore J.E. Regional tissue oxygen saturation in neonates: a systematic review and metaanalysis. Neonatology. 2021;118(2):123–134.

15. Ling N., Li C.L., Wang Z.Z., Zhang H.N., Xu H., An X.I. Heart rate variability in children with myocarditis presenting with ventricular arrhythmias. European Review for Medical and Pharmacological Sciences. 2018;22(4):1102–1105.

16. Bissel S.J., Winkler C.C., DelTondo J., et al. Coxsackievirus B4 myocarditis and meningoencephalitis in newborn twins. Neuropathology. 2014;34(5):429–437.


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For citations:


Polikarpova I.I. Myocarditis in Newborns and Cerebral Ischemia: A Systematic Analysis of Cardiocerebral Interactions in the Neonatal Period. Vestnik of North-Eastern Federal University. Medical Sciences. 2026;44(3):62-72. (In Russ.) https://doi.org/10.25587/2587-5590-2026-3-62-72

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