CLINICAL CHARACTERISTICS OF VIRAL HEPATITIS C IN THE SAKHA REPUBLIC (YAKUTIA)

Abstract

The Sakha Republic (Yakutia) is considered an unfavorable region of the Russian Federation in terms of the viral hepatitis C prevalence, as well as high incidence of cirrhosis and liver cancer in HCV-infected individuals. The aim of the study was to describe the course of chronic HCV infection in patients from the Sakha Republic (Yakutia) to improve the complex of personalized approaches in the management of this group of patients. The study included 175 case histories of patients with chronic viral hepatitis C, 72 (41.2 %) men and 103 (58.8 %) women, the average age 57.4 ± 2.1 years. The diagnosis of chronic hepatitis C was established basing on anamnestic data, as well as the results of physical, laboratory and instrumental examinations. The dynamics of the incidence of chronic hepatitis C in the period 2008-2018 in the Sakha Republic (Yakutia) was characterized by different intensity of the epidemic process; over the entire period of observation, the overall incidence of chronic hepatitis C was on average higher than the national average. During PCR analysis, HCV RNA was detected in 89.7 % of the patients with CHC, genotype 1c was isolated in 65 %, 3a - in 20 %, and genotype 2 - in 15 %. A high incidence of extrahepatic manifestations of patients with chronic HCV infection was determined (47.1 %).