THE CLINICAL CASE OF THROMBOPHILIA IN A YOUNG PATIENT WITH ISCHEMIC STROKE

Young patients can develop stroke under a variety of conditions, some of which are quite rare. Thrombophilia is one of the probable and important causes of stroke in young patients. The incidence of stroke at a young age is an important socio-economic problem for both the state and society as a whole. The combination of the patient’s diagnosis of thrombophilia and various risk factors, such as dyslipidemia, diabetes mellitus, arterial hypertension, smoking, etc. leads to an increased likelihood of developing a stroke. Thrombophilia can be hereditary and acquired. For hereditary thrombophilia, the carriage of certain polymorphisms of genes responsible for the coagulation properties of blood is characteristic. In clinical practice, molecular genetic studies are conducted on polymorphisms of coagulation factor genes. Of greatest interest is the determination of the carriage of polymorphisms of the PAI-1 gene, responsible for the inhibition of type 1 plasminogen activator. Identification of the mutant homozygous of this gene may be associated with the risk of developing ischemic stroke at a young age. The harbingers of a stroke in this group of patients are often transient cerebrovascular accidents (transient ischemic attacks) that occur before a stroke. Unfortunately, often such symptoms are ignored by patients or remain unrecognized and only subsequently identified retrospectively.

cardiovascular diseases, ischemic stroke, thrombophilia, transient ischemic attack, hypercoagulation, fibrinolysis, molecular genetic research, genetic polymorphisms, mutant homozygotes, heredity

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