ATYPICAL COURSE OF THE GENERALIZED FORM OF MENINGOCOCCAL INFECTION SEROTYPE W IN YOUNG CHILDREN
https://doi.org/10.25587/2587-5590-2024-4-26-34
Abstract
Meningococcal infection (MI) is a current disease with a wide range of clinical manifestations and an aggressive course. The clinical picture of meningococcal infection is characterized by polymorphism of manifestations from asymptomatic to extremely severe forms, leading to death within a few hours. The risk group for MI are children under 5 years of age. The GFMI can be caused by 6 serogroups: A, B, C, W, X and Y. Serotype W had not been registered in the Sakha Republic (Yakutia) until recently. With the MI caused by Neisseria meningitidis W, a number of authors note the polymorphism of the clinical picture of the generalized form of meningococcal infection. The presence of various atypical manifestations is characteristic. The article presents three clinical cases of patients with generalized meningococcal infection caused by Neisseria meningitidis, two of whom had the disease caused by serogroup W. Three young patients with similar clinical picture had no contacts confirmed by epidemiological investigation. All three had an atypical onset of the disease, with gastrointestinal syndrome. Eventually, all developed the clinical picture of severe meningoencephalitis. The peculiarity of these cases is isolated meningoencephalitis, without meningococcemia, which is the least common among generalized forms of meningococcal infection. Two patients were diagnosed with mixed infection with Epstein-Barr virus. One patient developed arthritis, according to the classification, related to rare forms of MI. In all patients, the outcome of the disease was sensorineural hearing loss.
About the Authors
T. G. Dmitrieva
Institute of Medicine, M. K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
DMITRIEVA Tatiana Gennadievna – Dr. Sci. (Medicine), Professor, Department of Pediatrics and Pediatric Surgery
677016, Yakutsk, ul. Oyunskogo, 27
Phone: +7 914 231 08 39
Zh. V. Kozhukhova
Children’s Clinical Infectious Diseases Hospital
Russian Federation
Russian Federation
KOZHUKHOVA Zhanna Vitalievna – head, Department of Infectious Bacterial Diagnostics
677005 Yakutsk, ul. Kurashova, 91/3
Phone: +7 968 156 93 10
V. P. Suzdаlova
Children’s Clinical Infectious Diseases Hospital
Russian Federation
Russian Federation
SUZDАLOVA Varvara Petrovna – physician, Department of Infectious Bacterial Diagnostics
677005 Yakutsk, ul. Kurashova, 91/3
Phone: +7 964 4152508
S. M. Mamontova
Children’s Clinical Infectious Diseases Hospital
Russian Federation
Russian Federation
MAMONTOVA Sardana Mirovna – physician, Department of Infectious Bacterial Diagnostics
677005 Yakutsk, ul. Kurashova, 91/3
Phone: +7 964 0778854
L. Z. K. Agaeva
Institute of Medicine, M. K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
AGAYEVA Leila Ziyafat Kyzy – student, Pediatric Department
677016, Yakutsk, ul. Oyunskogo, 27
Phone: +7 924 8667114
References
1. Fazio C., Neri A., Vacca P. et al. Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016. Euro Surveill. 2019; 24(4):1800183. DOI: 10.2807/1560–7917.ES.2019.24.4.1800183
2. Ivanova M.V. Skripchenko N.V., Vil’nic A.A. i dr. Osobennosti techenija generalizovannoj meningokokkovoj infekcii, vyzvannoj meningokokkom serogruppy W135.Detskie infekcii. 2016; 4:57–60. (in Russian)
3. Pelton S.I. The Global Evolution of Meningococcal Epidemiology Following the Introduction of Meningococcal Vaccines. Adolesc Health. 2016; 59 (2):3–11. DOI: 10.1016/j.jadohealth.2016.04.012
4. Peterson M.E., Li Y., Bita A., Moureau A., et al. Meningococcal serogroups and surveillance: a systematic review and survey. J Glob Health. 2019; 9(1):010409. DOI: 10.7189/jogh.09.010409
5. Russcher A., Fanoy E., van Olden G.D.J. et al. Necrotising fasciitis as atypical presentation of infection with emerging Neisseria meningitidis serogroup W (MenW) clonal complex 11, the Netherlands. March 2017. Euro Surveill. 2017; 22(23): 30549. DOI: 10.2807/1560-7917.ES.2017.22.23.30549
6. Mustapha M.M., Marsh J.W., Harrison L.H. Global epidemiology of capsular group W meningococcal disease (1970–2015): Multifocal emergence and persistence of hypervirulent sequence type (ST)-11 clonal complex. Vaccine. 2016; 34(13):1515–1523. DOI: 10.1016/j.vaccine.2016.02.014
7. Koroleva M.A., Mironov K.O., Koroleva I.S. Jepidemiologicheskie osobennosti generalizovannoj formy meningokokkovoj infekcii, obuslovlennoj Neisseria meningitidis serogruppy W, v mire i Rossijskoj Federacii. Jepidemiologija i infekcionnye bolezni. Aktual’nye voprosy. 2018; 3:16–23. (in Russian)
8. Lobzin Ju.V., Skripchenko N.V., Markova K.V. i dr. Semejnye sluchai meningokokkovoj infekcii, vyzvannoj Neisseria meningitidis serogruppy W. Pediatrija. Zhurnal im. G.N. Speranskogo. 2019; 98(1):242– 245. (in Russian)
9. Lobzin Ju.V., Skripchenko N.V., Vil’nic A.A. i dr. Kliniko-jepidemiologicheskie aspekty generalizovannoj meningokokkovoj infekcii u detej i podrostkov Sankt-Peterburga. Zhurnal infektologii. 2016; 8(1):19–25. (in Russian)
10. Matosova S.V., Mironov S.V., Platonov A.E. i dr. Molekuljarnobiologicheskij monitoring N. meningitidis na territorii Moskvy s 2011 po 2015 g. Jepidemiologija i infekcionnye bolezni. 2016; 2:4–9. (in Russian)
11. Mironov K.O., Zhivotova V.A., Matosova S.V. i dr. Harakteristika Neisseria meningitidis serogruppy W, cirkulirujushhej na territorii Moskvy, s pomoshh’ju massovogo parallel’nogo sekvenirovanija. Jepidemiologija i vakcinoprofilaktika. 2017; 4(95):33–38. (in Russian)
12. Nagibina M.V., Vengerov Ju.Ja., Matosova S.V. i dr. Generalizovannaja forma meningokokkovoj infekcii, vyzvannaja N. meningitidis serogruppy W, na territorii g. Moskvy v 2011–2016 gg. Infekcionnye bolezni: novosti, mnenija, obuchenie. 2018; 1(24):100–105. (in Russian)
13. O sostojanii sanitarno-jepidemiologicheskogo blagopoluchija naselenija v Rossijskoj Federacii v 2017 godu: Gosudarstvennyj doklad. M.: Federal’naja sluzhba po nadzoru v sfere zashhity prav potrebitelej i blagopoluchija cheloveka, 2018; 268. https://www.rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=10145 (in Russian)
14. Hellum M, Ovstebo R, Brusletto BS et al. Microparticleassociated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock. Thromb Res. 2014; 133: 507–514
15. Ladharri S.N., Beebeejaun К., Lucidarme L. et al. Increasein endemic Neisseria meningitidis capsular group W sequence type 11 complex associated with severe invasive disease in England and Wales. Clin. lnfect. Dis. 2015; 60(4):578–85.
16. Bethea J., Makki S., Gray S. et al. Clinical characteristics and public health management of invasive meningococcalgroup W disease in the East Midlands region of England, United Kingdom, 2011 to 2013. Euro Surveill. 2016; 21(24). DOI: 10.2807/1560-7917.ES.2016.21.24.30259
17. Knol M., Ruijs W.L.M., Melker H.E. et al. Plotselinge toename van invasieve meningokokkenziekte serogroep W in 2015 en 2016. Infectieziekten Bulletin. 2017; 28 (1):23–28.
18. Abad R., Vázquez J.A. Early evidence of expanding W ST-11 CC meningococcal incidence in Spain. J Infect. 2016; 73(3):296–297. DOI: 10.1016/j.jinf.2016.06.010
19. Bratcher H.B., Corton C., Jolley K.A. et al. A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes. BMC Genomics. 2014; 15: 1138. DOI: 10.1186/1471-2164-15-1138
20. Mohamed Issa, Paula Mölling, Magnus Unemo et al. Neisseria meningitidis serogroup W-135 isolated from healthy carriers and patients in Sudan after the Hajj in 2000 Scand. J Infect Dis. 2003; 35(4):230.
21. Popovic T., Sacchi C.T., Reeves M.W., et al. Neisseria meningitidis serogroup W135 isolates associated with the ET-37 complex. Emerg Infect Dis. 2000; 6:428–429
22. Aguilera J.F., Perrocheau A., Meffre C. et al. Outbreak of serogroup W135 meningococcal disease after the Hajj pilgrimage, Europe, 2000. Emerg Infect Dis. 2002; 8:761–767.
23. On the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2022: State report. M.: Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 2022; 370. https://rospotrebnadzor.ru/upload/iblock/b50/t4kqksh4b12a2iwjnha29922vu7naki5/GD-SEB.pdf (in Russian)
Review
For citations:
Dmitrieva T.G., Kozhukhova Zh.V., Suzdаlova V.P., Mamontova S.M., Agaeva L.Z. ATYPICAL COURSE OF THE GENERALIZED FORM OF MENINGOCOCCAL INFECTION SEROTYPE W IN YOUNG CHILDREN. Vestnik of North-Eastern Federal University. Medical Sciences. 2024;(4):26-34. (In Russ.) https://doi.org/10.25587/2587-5590-2024-4-26-34
Views:
93
Email this article 