THE COURSE OF TUBERCULOSIS IN CHILDREN AND ADOLESCENTS WHO HAVE SUFFERED COVID-19 IN YAKUTIA

This article presents the results of studying the course of tuberculosis infection in children and adolescents who have suffered COVID-19 according to a study of ELISA with the presence of Ig G in the blood. The follow-up included 54 patients aged 2 to 16 years with local forms of tuberculosis who were treated in the inpatient conditions of the children’s department of the E.N. Andreev Scientific and Practical Center of Phthisiology from 2020 to 2022. The patients were divided into two groups: the first group – children who had suffered from COVID-19 according to the results of IgG in the blood – 17 patients; the second group – those who had not had COVID-19 with negative results in IgG blood – 37 patients. A comparative medical and social analysis revealed that children who had had COVID-19 had both social and medical risk factors, as well as a burdened epidemiological history, contact with adult patients with acute progressive and destructive forms of pulmonary tuberculosis. Methods of detecting the tuberculosis process in the first group, 88 % of children were detected by contact, 6 % by treatment, 6 % by immunodiagnostics; in the second group, 51 % by contact, 8 % by treatment and 41 % by immunodiagnostics of the patients. In the study of the tuberculosis process in children of the first group, the infiltration phase was recorded in 80 % patients in the reverse development phase: resorption – 10 % and in the calcification phase – 10 %. In the second group, the infiltration phase was in 50 % of children, the resorption phase was in 14 %, and the calcification phase was in 36 % of patients. It should be noted that the effect of a previously transmitted new coronavirus infection on the course and outcomes of the tuberculosis process was not revealed, no correction of chemotherapy was required, and there was no need to increase the duration of treatment.

1. Aksenova V.A., Sterlikov S.A., Kucherjavaja D.A., Gordina A.V., Pankova Ja. Ju., Vasil’eva I.A. Jepidemicheskaja situacija po tuberkulezu u detej v 2021 g. i perspektivy ee dinamiki v 2022 g. // Tuberkuljoz I bolezni ljogkih. – 2022. – T. 100, No 11. – S. 13 – 19. http://doi.org/10.21292/2075-1230-2022-100-11-13-19

2. Vlasova E. Ju. Profilaktika tuberkuleza u detej iz grupp povyshennogo riska zabolevanija s ispol’zovaniem specificheskih i nespecificheskih sredstv : avtoref. dis. ... kand. med. nauk / Vlasova E. Ju. – SPb, 2009. – 23 s.

3. Gubkina M.F., Petrakova I.Ju., Juhimenko N.V., Sterlikova S.S., Hohlova Ju. Ju., Amansahedov R.B. Vspyshka novoj koronavirusnoj infekcii v detskom tuberkuleznom otdelenii // Tub. i bolezni legkih. – 2020. – T. 98, No 10. – S. 6 –10.

4. Ovsjankina E.S., Panova L.V., Gubkina M.F., Jergeshov A.Je., Petrakova I.Ju., Krushinskaja E.A. Tuberkulez i COVID-19 u detej i podrostkov – dve volny pandemii: opyt i vyvody. Tuberkulez i bolezni legkih. 2022; 100(2): 6 – 12. https://doi.org/10.21292/2075-1230-2022-100-2-6-12

5. Sevost’janova T.A., Bogdanova E.V., Nozdrevatyh I.V., Osmanov I.M., Samitova Je.R. Osobennosti klinicheskih projavlenij i lechenija soche-tanija tuberkuleza i novoj koronavirusnoj infekcii u detej // Tub. i social’no-znachimye zabolevanija. – 2020. – No 3. – S. 32 – 38.

6. Jergeshov A.Je, Ovsjankina E.S., Gubkina M.F., Petrakova I.Ju., Panova L.V., Hiteva A.Ju., Krushinskaja A.Ju. Osobennosti diagnostiki i techenija novoj koronavirusnoj infekcii u detej i podrostkov s tuberkulezom organov dyhanija // Vestnik CNIIT. – 2020. – No 4. – S. 43 – 48.