CARDIOVASCULAR SYSTEM SENSITIVITY TO GEOMAGNETIC DISTURBANCES IN THE ARCTIC ZONE OF THE SAKHA REPUBLIC (YAKUTIA) AND GENE POLYMORPHISMS REGULATING BLOOD PRESSURE

Arterial hypertension plays an important role in human pathology due to their participation in the mechanisms of cardiovascular complications development. The identification of the causes and main mechanisms of the development of arterial hypertension remain topical issues of modern medicine. The paper presents the results of a study aimed at identifying the relationship between the development of arterial hypertension and heliogeophysical disturbance at high latitudes (Tiksi, Arctic zone of the Sakha Republic (Yakutia)). The coincidence of the maxima of the temporal change in geomagnetic disturbance (Kp-index) and the number of calls of people to the ambulance service and the polyclinic of the Central hospital of Bulunsky District for arterial hypertension (AH) in 2017 was found. The patients with primary (essential) hypertension experienced hypertensive crises 2 - 3 times more likely on days of increased geophysical disturbance. The article presents the results of studying the frequencies of single nucleotide polymorphisms of genes encoding the enzyme responsible for the synthesis of aldosterone (CYP11B2 -344 T> C); guanine, a nucleotide binding protein (GNB3 825 C> T); an enzyme involved in the synthesis of nitric oxide (NOS3 -786 T> C and 894 G> T) in different ethnic groups of residents suffering from arterial hypertension.in the Arctic zone of the Sakha Republic (Yakutia).

arterial hypertension, cardiovascular system, cardiovascular diseases, heliogeophysical factors, geomagitic disturbance, single nucleotide polymorphisms, Arctic zone

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