Characteristics of the main causes of neglected malignant neoplasms in the oral mucosa and maxillofacial area

The presented review provides information on the characteristics of the main causes of neglected malignant neoplasms (MN) in the oral mucosa and maxillofacial area. To evaluate these literary sources, PubMed, Google Scholar, and E-Library materials were used, devoted to the main topic of the article. The treatment of patients in late-stage medical institutions has a wide range of causal factors covering various medical and social aspects. Among the main common causes of neglected fever in the oral cavity and maxillofacial area are particularly mild symptoms in the early stages. At the same time, there is a low level of awareness of the disease among patients, one third of whom refuse to carry out diagnostic measures and timely organization of therapeutic and preventive measures. The majority of the population of the Russian regions has a low level of sanitary awareness, which has a direct impact on morbidity rates and their detection in the late stages of acute respiratory viral infections. To a certain extent, iatrogenic factors may affect the late treatment of patients at stages III and IV, which are associated with a violation of the principle of oncological alertness at dental outpatient and inpatient appointments, as well as insufficient modern diagnostic equipment. In addition, there is insufficient coverage of the population during screening activities, which increases the rates of neglect. In general, the low level of public health awareness in matters of “oncological alertness” and the prevention of precancerous diseases, inadequate coverage of the population in the framework of medical examinations and oncological examinations of the oral cavity at the dentist’s office, to a certain extent, have an impact on the “neglect” of the disease. This situation requires research aimed at the prevention and early detection of precancerous and oncological diseases, as well as optimal routing of patients with acute respiratory viral infections in the early stages of their development.

1. Trizna N.M., Kolyadich Zh.V., Sharshakova T.M., Evmenenko A.A. Analysis of the quality of life of patients with locally advanced tumors of the oral and oropharyngeal mucosa. Problems of Health and Ecology. 2021;18(1):102–108 (in Russian).

2. Trizna N.M., Kolyadich Zh.V. Experience of conducting the European head and neck tumors early diagnosis week in the Republic of Belarus. Eurasian Oncological Journal. 2021;9(1):9-15 (in Russian).

3. Trizna N.M., Kolyadich Zh.V., Zhaleiko E.A., Evmenenko A.A. Dynamics of patients’ quality of life as a method for assessing the results of surgical treatment of oral and oropharyngeal cancer. Oncology and Radiology of Kazakhstan. 2021;1:31–35 (in Russian).

4. Trizna N.M., Kolyadich Zh.V., Kuzmin E.N., et al. Epidemiological characteristics and analysis of antibiotic sensitivity of key pathogens of postoperative infectious complications in patients with oral and pharyngeal tumors. Modern Dentistry. 2021;1:63–67 (in Russian).

5. Trizna N.M., Zhukovets A.G., Kolyadich Zh.V. Medical rehabilitation of patients with oral and oropharyngeal tumors. Oncological Journal. 2021;15(1):57–62 (in Russian).

6. Zhukovets A.G., Belotserkovsky I.V., Trizna N.M., et al. The role of the dentist in the early diagnosis of oral mucosa cancer. Minsk: Branch No. 1 of JSC “Krasnaya Zvezda”. 2012;38–41 (in Russian).

7. Trizna N.M., Kolyadich Zh.V., Zhaleiko E.A. Medical rehabilitation of patients with tumors of the oral and oropharyngeal mucosa. In: Abdukadyrov A.A. et al. (eds.) Current Issues and New Technologies in Maxillofacial Surgery: Proceedings of the International Scientific and Practical Conference, Tashkent, November 27, 2020. Tashkent. 2020;71–74 (in Russian).

8. Kolyadich Zh.V., Zhukovets A.G., Trizna N.M., et al. Don’t Miss Cancer! For the General Practitioner, Otorhinolaryngologist, Dentist: A Practical Guide. Retsept. 2020;23(2):104 (in Russian).

9. Adamovich E.I., Makedonova Yu.A., Marymova E.B. Rationale for new methods of diagnosis and treatment of erosive-ulcerative form of oral lichen planus. Modern Problems of Science and Education. 2016;1:27. Available at: https://s.science-education.ru/pdf/2016/1/24123.pdf. (in Russian)

10. Alieva G.K., Damircheva M.V., Kerimli N.K. Review of methods for prevention of oral leukoplakia. Bulletin of Science and Education. 2021;6(109):85–88 (in Russian).

11. Allakhverdiyeva G.F., Sinyukova G.T., Sholokhov V.N. Modern problems of diagnosis of head and neck tumors. Oncology Journal: Radiation Diagnostics, Radiation Therapy. 2020;3(3):13–34 (in Russian).

12. Bayrikov I.M., Monakov D.V., Shcherbovskikh A.E. Rehabilitation of patients with oncological diseases of the maxillofacial area. In: Kotelnikov G.P.,. Izmalkov S.N. (eds.). Current Problems of Additional Professional Education and Healthcare: Proceedings of the Interregional Scientific and Practical Conference dedicated to the 30th anniversary of the Institute of Postgraduate Education of Samara State Medical University. Samara. 2013;119–120 (in Russian).

13. Bondarenko O.V., Tokmakova S.I., Pobedinskaya L.Yu. Early diagnosis of oral mucosal diseases using f luorescence. Health and Education in the 21st Century. 2017;19:626–629 (in Russian).

14. Bulgakova N.N., Volkov E.A., Pozdnyakova T.I. Autofluorescence stomatoscopy as a method of oncological screening for oral mucosal diseases. Russian Dental Journal. 2015;19(1):27–30 (in Russian).

15. Gershtein E.S., Kushlinsky N.E. Clinical prospects for the study of tumor-associated proteases and their tissue inhibitors in cancer patients. Bulletin of the Russian Academy of Medical Sciences. 2013;5:16–27 (in Russian). DOI: 10.15690/vramn.v68i5.659

16. Gorbatova E.A., Kozlova M.V., Glybina T.A. Methods of optical diagnostics for early detection of malignancy of oral mucosal lesions (systematic review). Kremlin Medicine. Clinical Bulletin. 2020;23(1):119 123 (in Russian).

17. Gorbatova E.A., Kozlova M.V., Zubarev A.V. Differential diagnosis of oral leukoplakia. Modern Dentistry. 2022;4(89):43–46 (in Russian).

18. Gorbatova E.A., Kozlova M.V., Zubarev A.V. Rationale for choosing a treatment method for the flat form of oral leukoplakia. Chief Physician of the South of Russia. 2022; 5(86):12–15 (in Russian).

19. Gorbatova E.A., Kozlova M.V., Zubarev A.V. Modern principles of managing patients with oral leukoplakia. Kremlin Medicine. Clinical Bulletin. 2022;25(3):46–50 (in Russian).

20. Gorbatova E.A., Kozlova M.V., Zubarev A.V. Modern aspects of diagnosing various forms of oral leukoplakia. Flagman of Science: Scientific Journal. 2023;4(4):186–191 (in Russian).

21. Gorbatova E.A., Kozlova M.V. In: The significance of biological markers at the stages of monitoring patients with verrucous leukoplakia of the oral mucosa. High Technologies and Innovations in Science: Proceedings of the XLVI International Scientific Conference. Tyumen. St. Petersburg: National Development; 2023:15–19 (in Russian).

22. Gorbatova E.A., Kozlova M.V., Lobachyova E.V. Detection of malignancy of precancerous oral mucosal diseases. Kremlin Medicine. Clinical Bulletin. 2020;32(3):33–37 (in Russian).

23. Danilina E.F., Zhidovinov A.V. Galvanosis as a factor in the occurrence and development of precancerous diseases of the oral mucosa. Volgograd Scientific Medical Journal. 2012;3:37–39 (in Russian).

24. Dzhuraeva Sh.F., Chistenko G.N., Terekhova T.N., et al. Oral cancer: risk factors and screening. International Reviews: Clinical Practice and Health. 2020;2:7–16 (in Russian).

25. Iivina A.A., Semkin V.A., Babichenko I.I. Cytokeratin 15 as a diagnostic marker for the onset of malignancy of the oral mucosal epithelium. Stomatologiya. 2018;6:61–62 (in Russian). DOI: 10.17116/stomat20189706161

26. Karpenko A.V., Sibgatullin R.R., Boyko A.A. Dynamics of quality of life in patients with oral cancer who underwent combined comprehensive treatment and its clinical significance. Head and Neck Tumors. 2018;8(4):39 47 (in Russian).

27. Grinin V.M., Kovaleva L.S. Organization of dental care for patients with various somatic pathologies. Problems of Social Hygiene, Public Health and History of Medicine. 2018;26(2):115–118 (in Russian).

28. Kochurova E.V., Kudasova E.O., Nikolenko V.N. The role of oral fluid biomarkers in the diagnosis of oral mucosa cancer. Voprosy Onkologii. 2022;68(5):565–570 (in Russian). DOI:10.37469/0507-3758-2022-68 5-565-570

29. Inzhina E.V., Kochurova E.V., Seferyan K.G. The impact of antitumor treatment on the dental status of patients with malignant neoplasms of the oropharyngeal region. Kuban Scientific Medical Bulletin. 2017;24(5):111–119 (in Russian). https://doi.org/10.25207/1608-6228-2017-24-5-111-119.

30. Paches A.I., Olshansky V.O., Lyubaev V.L., et al. Malignant tumors of the oral cavity, pharynx and larynx. Moscow: Meditsina; 1988:302 (in Russian).

31. Kamilov Kh.P., Kadyrbayeva A.A., Gaybulayev E.A. In: Early detection of precancerous lesions of the oral cavity. Innovative Strategy for the Development of Fundamental and Applied Scientific Research: Past Experience – A Look into the Future: Proceedings of the International Scientific and Practical Conference. St. Petersburg: Kult-InformPress; 2016:36–37 (in Russian).

32. Ikonnikova A.V., Dzhuraeva Sh.F. Oncological alertness of dentists: issues of primary diagnosis of tongue cancer. Modern Dentistry. 2019;2:46–48 (in Russian).

33. Ahmadova M.A., Soikher M.I., Chuyanova E.Yu. Oncological alertness in the practice of a dentist. Medical Alphabet. 2016;2(9):6–9 (in Russian).

34. Rakhmankulova G.S., Tulebayev K.A., Zholdybaev S.S. Oncological alertness in oral diseases (literature review). Bulletin of KazNMU. 2017;1:168–172.

35. Lobacheva E.V., Gorbatova E.A., Kozlova M.V. Early methods for establishing tumor transformation of oral mucosal diseases. Proceedings of the All-Russian Dental Forum, February 11–13, 2021. Moscow. Russia. Russian Dentistry. 2021;14(1):31–76 (in Russian). DOI:10.17116/rosstomat20211401131

36. Lukina G.I., Abramova M.Ya., Belyaeva Yu.G. Complex methods in the treatment of precancerous diseases of the oral mucosa. Proceedings of the 17th All-Russian Dental Forum and Fair “DENTAL-REVIEW 2020”, February 10–12, 2020. Moscow. Russia. Russian Journal of Dentistry. 2020;3:34–5 (in Russian).

37. Lukinykh L.M., Tiunova N.V. Local immunomodulators in the complex treatment of erosive-ulcerative form of oral lichen planus. Stomatologiya. 2013;92(6):26–28 (in Russian).

38. Zhou J., Ji Q., Li Q. Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies. Journal of Experimental & Clinical Cancer Research. 2021;40:328.

39. Zhernakova D.V., Brukhin V., Malov S., et al. Genome-wide sequence analyses of ethnic populations across Russia. Genomics. 2020;112(1):442–458.

40. Zaniboni A. A, Ghidini M., Grossi F., et al. Review of Clinical Practice Guidelines and Treatment Recommendations for Cancer Care in the COVID-19 Pandemic. Cancers. Basel. 2020;12(9):2452.

41. Yu S.S., Cirillo N. The molecular markers of cancer stem cells in head and neck tumors. Journal of Cellular Physiology. 2020;235(1):65–73.

42. Yazdanian A. A, Ayatollahi H., Nahvijou A. Conceptual Model of an Oncology Information System. Cancer Management and Research. 2020;l:12:6341–6352.

43. Yang, X., Chen H., Sang S., et al. Burden of All Cancers Along With Attributable Risk Factors in China From 1990 to 2019: Comparison With Japan, European Union, and USA. Frontiers in Public Health. 2022;10:862165.

44. Yamagiwa Y. A, Tanaka S., Abe S.K., et al. Cross-sectional survey on awareness of cancer risk factors, information sources and health behaviors for cancer prevention in Japan. Scientific Reports. 2022;12(1):14606.

45. Xie D., Chen X., Wu H., et al. Prediction of Diagnostic Gene Biomarkers Associated with Immune Infiltration for Basal Cell Carcinoma. Clinical, Cosmetic and Investigational Dermatology. 2022;15:2657–2673.

46. Williams J.B., Li S., Higgs E.F., et al. Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells. Nature Communications. 2020;1:602.

47. Wang, Y., Kremer L.C.M., van Leeuwen F.E., et al. Cohort profile: Risk and risk factors for female breast cancer after treatment for childhood and adolescent cancer: an internationally pooled cohort. BMJ Open. 2022;12(11):065910.

48. VanderWalde A. Personalized Medicine in Oncology; a Special Issue of the Journal of Personalized Medicine. Journal of Personalized Medicine. 2021;11(7):632.