THE STATE OF THROMBOTIC READINESS IN CARDIAC PATIENTS WITH A BURDENED ONCOLOGIC HISTORY: THE SEVERITY OF THE PROCESS IN THE PRESENCE OF INDIVIDUAL RISK FACTORS

Thrombotic events are frequent complications in patients with a cardiac profile, the probability of which, according to some authors, increases in the presence of traditional cardiovascular risk factors (gender, obesity, etc.). In real clinical practice, diagnostics of prethrombotic status – the state of thrombotic readiness (STH) is of great importance. It has been established that STH is detected in almost half of patients with cardiovascular pathology and an aggravated oncologic anamnesis; however, the influence of cardiovascular risk factors on the severity of STH in this category of patients has not been assessed. Objective: to assess the influence of gender and the presence of excess body weight/obesity on the severity of the state of thrombotic readiness according to thrombodynamic characteristics of blood in cardiac patients with an aggravated oncologic anamnesis. Material and methods. 100 patients with cardiac pathology and an aggravated oncologic anamnesis were examined. The global test for assessing the hemostasis system state, the Thrombodynamics test, was used to analyze the hemocoagulation status. Results. STH was diagnosed in 51 patients based on the thrombodynamic characteristics of the blood in accordance with the required criteria, and the influence of gender and excess body weight/obesity on the severity of the detected hypercoagulation changes was analyzed. The subgroups of men and women amounted to 11 people and 40 people, respectively. The subgroup of patients with normal body weight included 14 people, with excess body weight/obesity – 37 people. It was found that the severity of hypercoagulation changes in thrombodynamic velocity and structural parameters is comparable in men and women (p> 0.05), as well as in patients with and without excess body weight/obesity (p> 0.05). Conclusion. The obtained data indicate that in comorbid patients with a combination of cardio- and oncopathology in the conditions of prethrombotic state (STG), there is a modification of the influence of such traditional cardiovascular risk factors as male gender and overweight/obesity. This is important to take into account in real clinical practice.

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