EPIDEMIOLOGICAL FEATURES OF ENTEROVIRUS MENINGITIS IN THE RUSSIAN FAR EAST

The article presents data on the prevalence of enterovirus meningitis in the Far Eastern Federal District for the period from 2010 to 2023. Enterovirus meningitis was registered in all territories of the Far Eastern Federal District. The maximum incidence rates were detected in Khabarovsk Krai. The maximum indicators for Khabarovsk Krai, statistically exceeding all subjects of the Far Eastern Federal District, are probably the result of effective laboratory diagnostics, and not the presence of additional risk factors for the development of the epidemic process. Sakhalin Oblast ranked second, followed by Jewish Autonomous Oblast. In addition, clinical manifestations of enterovirus infection in the form of meningitis were steadily formed only in Primorsky Krai and Amur Oblast. These subjects can be considered as endemic for enterovirus infection, clinically manifested by meningitis. There are no grounds to classify Chukotka Autonomous Okrug, Magadan Oblast, Kamchatka Krai and the Sakha Republic as endemic for enterovirus infection manifested by meningitis. In some years, the proportion of enterovirus meningitis ranged from 8 to 58 % of enterovirus infection. Enteroviruses Echo (53.2 %), Coxsackie A (29.8 %) and Coxsackie B (17 %) were isolated from patients. No statistical association of enterovirus meningitis with certain serotypes of the pathogen was revealed. The main age groups of patients with enterovirus meningitis in the period from 2017 to 2022 were children of 3-6 years of age and 7-14-year-old schoolchildren. In the structure of computer patients, they accounted for 28.7-45.2 % and 39.3-62.6 %, respectively. A small proportion of cases (up to 3.4 %) occurred in children under the age of one year. From 3.1 to 14.2 % of the cases were represented by 1-2-year-old children. Persons aged 15-17 years accounted for 0.1-8.3 % of cases in the age structure of computer disease. The long-term dynamics of the incidence of enterovirus meningitis in endemic territories was characterized by the presence of cyclicity.

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