THE ACTIVITY OF FREE RADICAL PROCESSES IN THE BLOOD SERUM OF PATIENTS WITH LICHEN PLANUS ERYTHEMATOSUS OF THE ORAL MUCOSA

This research says that lichen ruber planus (LRP) has a wide range of clinical manifestations in the oral cavity, where the main morphological element of the lesion is papular rashes accompanied by inflammatory and proliferative processes. At the same time, the etiological factors and pathogenetic mechanisms of development are currently not fully understood. In many pathological conditions of the body, oxidative stress plays a leading role in the mechanism of damage to the structure of cell membranes, violation of their permeability, which is associated with increased production of reactive oxygen species, which have a pronounced reactive effect. For the state of oxidative stress (OS), first of all, it is typical to have an imbalance in the ratio of the pro- and antioxidant systems in the direction of strengthening the former, which possibly contributes to the development of inflammatory and destructive lesions in the COPR with CPL. The aim of the study was to study the activity of free radical processes in the blood serum of patients with CPL COPR for a selective approach to the appointment of corrective therapy. Materials and methods of research. The study of biochemiluminescence parameters was carried out in 66 recipients with CPL SOPR, age group from 35 to 65 years and a control group that included 33 people of similar age, without clinical manifestations of diseases of SOPR. The intensity of free radical processes in blood serum was assessed by chemiluminescence (CML) using the LS 50B “PERKIN ELMER” spectrometer. Spontaneous, Fe2+-induced and H2O2-initiated chemiluminescence in the presence of luminol was recorded. The obtained data were displayed in relative units. Results. The obtained results by the method of chemiluminescence (CML) in serum in recipients with clinical LRP manifestations in the oral cavity determine the dynamic characteristic of intensification of free-radical processes. At the same time, actual data on the weakening of the antioxidant protection systems barrier (Ssp, h, Sind-1, Slum, H and Sind-2) were revealed compared to similar data of the control group. Discussion. CML indicators reflect an increase in the production of free radicals of a lipid nature and a weakening of the antioxidant barrier in individuals with CPL COPR, which indicates the development of OS in the body as a whole. Conclusion. Taking into account the development of the state of systemic OS in CPL COPR, it is justified to correct it in a timely manner by including antioxidants in the general treatment complex to reduce the duration of manifestations of lesions and to provide a positive effect of the therapy.

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