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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vfumed</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Северо-Восточного федерального университета имени М.К. Аммосова. Vestnik of North-Eastern Federal University. Серия «Медицинские науки. Medical Sciences»</journal-title><trans-title-group xml:lang="en"><trans-title>Vestnik of North-Eastern Federal University. Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2587-5590</issn><publisher><publisher-name>Северо-Восточный федеральный университет имени М.К. Аммосова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25587/SVFU.2019.1(14).27477</article-id><article-id custom-type="elpub" pub-id-type="custom">vfumed-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>ФАКТОРЫ РИСКА ИШЕМИЧЕСКОГО КАРДИОЭМБОЛИЧЕСКОГО ИНСУЛЬТА В ЯКУТИИ</article-title><trans-title-group xml:lang="en"><trans-title>Cardioembolic ischemic stroke risk factors in Yakutia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чугунова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chugunova</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">sa.chugunova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эверстова</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Everstova</surname><given-names>T. E.</given-names></name></name-alternatives><email xlink:type="simple">selectir_66@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаева</surname><given-names>Т. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaeva</surname><given-names>T. I.</given-names></name></name-alternatives><email xlink:type="simple">tyanic@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медицинский институт ФГАОУ ВО “Северо-Восточный федеральный университет имени М.К. Аммосова”</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Institute of Medicine, M.K. Ammosov the North-Eastern Federal University named after M.K. Ammosov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Медицинский институт ФГАОУ ВО “Северо-Восточный федеральный университет имени М.К. Аммосова”</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Medicine, M.K. Ammosov North-Eastern Federal University; Medical Institute of the North-Eastern Federal University named after M.K. Ammosov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>11</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>1</issue><fpage>51</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чугунова С.А., Эверстова Т.Е., Николаева Т.Я., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Чугунова С.А., Эверстова Т.Е., Николаева Т.Я.</copyright-holder><copyright-holder xml:lang="en">Chugunova S.A., Everstova T.E., Nikolaeva T.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.smnsvfu.ru/jour/article/view/9">https://www.smnsvfu.ru/jour/article/view/9</self-uri><abstract><p>Кардиоэмболический ишемический инсульт является актуальной проблемой сосудистой неврологии. Доля кардиоэмболического инсульта в общей структуре инсульта не имеет тенденции к снижению (BembenekJ.P и соавт., 2015). В исследованиях, проведенных в европейских и азиатских популяциях, установлено, что значительная часть пациентов с кардиоэмболическим инсультом не получала антикоагулянтной терапии для профилактики заболевания (AndrikopoulosG.и соавт., 2014; NakamuraA.и соавт., 2016). Особенности клинических характеристик и факторов риска заболевания в популяции Якутии нуждаются в дополнительных исследованиях. Проведено исследование с целью изучения факторов риска ишемического кардиоэмболического инсульта в группе пациентов, госпитализированных в Региональный сосудистый центр (Якутск). В группе исследования было 86 пациентов с кардиоэмболическим инсультом в острой стадии. Установлено, что самым распространенным фактором риска заболевания явилась фибрилляция предсердий. У 87,2 % пациентов заболевание развилось на фоне неклапанной фибрилляции предсердий, у 2,3 % - на фоне протезированных клапанов сердца, у 10,5 % - вследствие сочетания данных патологий. Постоянная форма фибрилляции предсердий диагностирована в 82,1 %, персистирующая форма - в 11,9 %, пароксизмальная форма - в 6 %. В 46,5 % случаев инсульт был повторным. Менее половины пациентов (48,8 %) получали антикоагулянтную терапию в качестве первичной и вторичной профилактики инсульта. У пациентов, принимавших антагонисты витамина К, в 91,9 % случаев кардиоэмболический инсульт развился на фоне субтерапевтических уровней медикаментозной гипокоагуляции. Необходимо оптимизировать стратегию профилактики кардиоэмболического инсульта в регионе, в том числе улучшить приверженность пациентов антикоагулянтной терапии и эффективно контролировать уровень медикаментозной гипокоагуляции.</p></abstract><trans-abstract xml:lang="en"><p>Cardioembolic ischemic stroke is a pressing issue of vascular neurology. The cardioembolic stroke proportion in the overall stroke structure does not tend to decrease (Bembenek J.P et al, 2015). Studies conducted in European and Asian populations have found that a significant proportion of cardioembolic stroke patients did not receive an anticoagulant therapy for the disease prevention (AndrikopoulosG. et al., 2014; Nakamura A. et al., 2016). Features of clinical characteristics and disease risk factors in the population of Yakutia need an additional research. This study was conducted to investigate cardioembolic ischemic stroke risk factors in the group of patients hospitalized in the Regional Vascular Center (Yakutsk). The study group included 86 patients with acute cardioembolic stroke. It was found that the most common disease risk factor was the atrial fibrillation. In 87.2 % of patients, the disease developed due to the non-valvular atrial fibrillation, in 2.3 % - due to prosthetic heart valves, in 10.5 % - due to a combination of these pathologies. The permanent form of atrial fibrillation was diagnosed in 82.1 %, the persistent form in 11.9 %, the paroxysmal form in 6 %. In 46.5 % of cases, it was a recurrent stroke. Less than in half of the cases (48.8 %), patients received the anticoagulant therapy for primary and secondary stroke prevention. 91,9 % of the patients who received vitamin K antagonists had the subtherapeutic level of hypocoagulation at the stroke onset. It is necessary to optimize the strategy of the cardioembolic stroke prevention, including improved patient’s compliance to anticoagulant therapy and effectively controlling the level of hypocoagulation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиоэмболический инсульт</kwd><kwd>фактор риска</kwd><kwd>фибрилляция предсердий</kwd><kwd>антикоагулянтная терапия</kwd><kwd>варфарин</kwd><kwd>международное нормализованное отношение</kwd><kwd>антиагреганты</kwd><kwd>гипокоагуляция</kwd><kwd>профилактика инсульта</kwd><kwd>антагонист витамина К</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardioembolic ischemic stroke</kwd><kwd>risk factor</kwd><kwd>atrial fibrillation</kwd><kwd>anticoagulant therapy</kwd><kwd>warfarin</kwd><kwd>international normalized ratio</kwd><kwd>antiplatelet agents</kwd><kwd>hypocoagulation</kwd><kwd>stroke prevention</kwd><kwd>vitamin K antagonist</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bembenek J.P., Karliński M., Kobayashi A. et al. 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