This article contains an analysis of the ACS mortality in 2020 in the Intensive Care Unit of the Regional Vascular Center No. 1, Republic’s Hospital No. 2 -Center for Emergency Medical Aid in 2020. The aim was to assess the mortality rates, the influence of concomitant diseases, age, and the coronavirus infection; to assess the impact of primary percutaneous coronary intervention (PCI) on survival in the department; and to improve the quality of medical services provided to the population. The study covered 115 patients who died in the Cardiac Intensive Care Unit. The severity of the condition at admission, concomitant diseases, and the effect of a new coronavirus infection were taken into account. Compared to 2019, the mortality rate increased by 83%. The factors that negatively affect the level of hospital mortality are as follows: cardiogenic shock, female sex, old and senile age, kidney disease, diabetes mellitus, previous myocardial infarction, hospitalization period, distance from the PCI center, and the severity of the condition upon admission. Concomitant pathologies were detected in more than 90% of the patients. The peculiarities of the course of coronavirus infection in patients with coronary artery disease have become an increase in the class of angina pectoris, an increase in the risk of acute coronary events; however, we have yet to study the effect of the new coronavirus infection and analyze the new data.